Just before using this medication, tell your medical professional or pharmacist For anyone who is allergic to any of its ingredients; or to opioid soreness relievers (including morphine); or For those who have almost every other allergies.
The phosphate salt of codeine occurs as white, needle-formed crystals or white crystalline powder. Codeine phosphate is freely soluble in h2o and marginally soluble in Alcoholic beverages.
Promethazine and codeine might cause marked drowsiness or could impair the mental and/or Actual physical capabilities necessary with the performance of potentially harmful jobs, such as driving a car or functioning equipment.
To help protect against withdrawal, your medical doctor may possibly decrease your dose gradually. Withdrawal is more likely When you've got applied this medication for many years (quite a lot of weeks) or in large doses. Inform your medical professional or pharmacist at once if you have withdrawal.
Promethazine needs to be used cautiously in persons with cardiovascular disease or with impairment of liver operate.
) Paradoxical Reactions- Hyperexcitability and abnormal movements happen to be noted in sufferers following a single administration of promethazine HCl. Thing to consider needs to be provided for the discontinuation of promethazine HCl also to the use of other medicine if these reactions happen. Respiratory depression, nightmares, delirium, and agitated actions have also been described in Many of these patients.
This medication could lead to hurt and death if taken by other Grownups, little ones, or Animals. It is important to get rid of the medication when you no more need it or it truly is expired. You can do this in two strategies:
Advise people that some folks have a genetic variation that brings about codeine switching into morphine more quickly and totally than Other individuals. Plenty of people are unaware of whether or not they are an ultra-quick codeine metabolizer or not. These increased-than-usual amounts of morphine inside the blood may lead to life-threatening or fatal respiratory melancholy or signs of overdose like Extraordinary sleepiness, confusion, or shallow respiration.
Lengthy-phrase animal experiments have not been executed to evaluate the carcinogenic potential of codeine or of promethazine, nor are there other animal or human data regarding carcinogenicity, mutagenicity, or impairment of fertility with these agents.
Respiratory despair resulting in arrest, coma, and Loss of life has happened with the usage of codeine antitussives in young children, specifically within the less than-a single-calendar year infants whose power to deactivate the drug is not absolutely produced.
Bronchial asthma Together with other Respiratory Ailments: Narcotic analgesics or cough suppressants, which includes codeine, should not be Utilized in asthmatic patients (see CONTRAINDICATIONS). Nor should they be Employed in acute febrile illness connected to productive cough or in Continual respiratory disease wherever interference with capability to clear the tracheobronchial tree of secretions would've a deleterious impact on the individual’s respiratory purpose. Hypotensive Outcome: Codeine may well create orthostatic hypotension in ambulatory clients.
If you are very sleepy or have problems waking up just after making use of this medication, prevent using this medication and speak to your medical doctor or pharmacist straight away. Your dosage could have to be decreased.
So, it was really crucial to observe what their reaction was. If I didn’t have a response, then I undergo the entire process of Promethazine codeine syrup re-messaging almost everything when I go back house for the following day.”
Codeine: Dosage of codeine Shouldn't be Improved if cough fails to respond; an unresponsive cough needs to be reevaluated in five days or faster for doable underlying pathology, including overseas human body or lessen respiratory tract disease. Codeine may possibly result in or aggravate constipation.